Organic Letters p. 2454 - 2457 (2015)
Update date:2022-07-29
Topics:
Miura, Tomoya
Funakoshi, Yuuta
Fujimoto, Yoshikazu
Nakahashi, Junki
Murakami, Masahiro
A sequential procedure for the synthesis of 2,5-disubstituted thiazoles from terminal alkynes, sulfonyl azides, and thionoesters is reported. A copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes with sulfonyl azides affords 1-sulfonyl-1,2,3-triazoles, which then react with thionoesters in the presence of a rhodium(II) catalyst. The resulting 3-sulfonyl-4-thiazolines subsequently aromatize into the corresponding 2,5-disubstituted thiazoles by elimination of the sulfonyl group. (Chemical Equation Presented).
View MoreABA Chemicals (Shanghai) Limited
Contact:021- 5115 9199-232
Address:Suite 18D, #201 Ningxia Road,
Shenyang Xingzhenghe Chemical Co., Ltd.
Contact:024-23509232
Address:No. 33, Naner Road, Heping Dist.
Wuxi Zuping Food Science And Technology Co.,LTD.
Contact:+86-510-87210822
Address:Guanlin town
Jiangsu Willing Bio-Tech Co ltd
website:http://www.willingbio.com/
Contact:+86 18796909136--
Address:No 18 Guoqiao Road
Yangzhou Zhongbao Pharmaceutical Co.,Ltd
Contact:+86-514-88290838
Address:Jiangsu Baoying county economic develpment zone in baoying avenue91
Doi:10.1021/jo00373a034
(1986)Doi:10.1016/j.jfluchem.2015.06.018
(2015)Doi:10.1021/jo800524h
(2008)Doi:10.1021/jf902153a
(2009)Doi:10.1021/jm800050t
(2008)Doi:10.1071/CH14659
(2015)
