Bioorganic and Medicinal Chemistry Letters p. 3224 - 3229 (2008)
Update date:2022-07-30
Topics:
Cai, Zhen-Wei
Wei, Donna
Schroeder, Gretchen M.
Cornelius, Lyndon A.M.
Kim, Kyoung
Chen, Xiao-Tao
Schmidt, Robert J.
Williams, David K.
Tokarski, John S.
An, Yongmi
Sack, John S.
Manne, Veeraswamy
Kamath, Amrita
Zhang, Yueping
Marathe, Punit
Hunt, John T.
Lombardo, Louis J.
Fargnoli, Joseph
Borzilleri, Robert M.
A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the discover
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(1954)
