Synthesis of Five- and Six-Membered Nitrogen Heterocycles via a Palladium(II)-Catalyzed Cyclization of Unsaturated Amides

Article abstract of DOI:10.1021/jo00371a041

Palladium(II)-catalyzed arylation of N-4-pentenyl-p-toluenesulfonamides 2 with ArSn(n-Bu)3 under oxidative conditions (CuCl2 in ether) provides either 2-arylpiperidines 5 or N-(chloro-5-arylpentyl)-p-toluenesulfonamides 6 depending on the kind of arylatin