Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels

Article abstract of DOI:10.1124/mol.108.046615

The 2H-1,4-benzoxazine derivatives are modulators of the skeletal muscle ATP-sensitive-K⁺ channels (K_ATP), activating it in the presence of ATP but inhibiting it in the absence of nucleotide. To investigate the molecular determinants