FR901469, a novel antifungal antibiotic from an unidentified fungus No. 11243. III. Structure determination

DOI: 10.7164/antibiotics.54.588

Source and publish data:

Journal of Antibiotics p. 588 - 594 (2001)

Update date:2022-07-30

Topics:

Authors:

Fujie Fujie

Muramatsu

Yoshimura

Hashimoto

Shigematsu

Takase Takase

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Article abstract of DOI:10.7164/antibiotics.54.588

A novel antifungal antibiotic, FR901469, was isolated from an unidentified fungus No. 11243. It is a water-soluble 40-membered macrocyclic lipopeptidolactone, consisting of D-Ala, L-Tyr, L-Val, trans-4OH-L-Pro, trans-3OH-L-Pro, threo-3OH-L-Gln, Gly, L-Orn, L-Thr, three residues of D-allo Thr and a (3R)-hydroxypalmitic acid. Its structure, including absolute configurations, was unequivocally determined as 1 based on chemical and spectroscopic evidence.

Full text of DOI:10.7164/antibiotics.54.588

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