COMPLEXATION D'IMINOPYRIDINES PAR LE SEL DE ZEISE: VOIE D'ACCES A DES CONJUGUES ESTRADIOL-cis-DICHLORO PLATINE. ETUDE STRUCTURALE DU COMPLEXE cis-PtCl2,H20

Article abstract of DOI:10.1016/0022-328X(86)80303-5

In order to synthesize penta- and hexa-gonal platinum(II) metallocycles, bidentate ligands such as iminopyridines (L) have been prepared and characterized.The (2-pyridil)CH=NR¹ and (2-pyridil)CH2N=CR¹R² ligands react with Zeise's salt to afford directly the pentagonal chelates PtCl2L.Their structure and the cis-stereochemistry were shown by the usual spectroscopic methods and for cis-PtCl2,H2O by an X-ray diffraction study.On the other hand, the (2-pyridil)(CH2)2N=CR¹R² ligands do not afford the expected hexagonal metallocycles; instead, after complexation at the nitrogen atom of the imine they give rise to the (2-pyridil)ethylamine complex formed after hydrolysis of the coordinated ligands.Complexes trans-<(2-pyridil)(CH2)2N=CR¹R²>-PtCl2 represent when R¹ is estradiol a model for "cytotoxic with delayed activity".