Directed reductive amination of β-hydroxy-ketones: Convergent assembly of the ritonavir/lopinavir core

DOI: 10.1021/ol062715y

Source and publish data:

Organic Letters p. 267 - 270 (2007)

Update date:2022-09-26

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Authors:

Menche, Dirk

Arikan, Fatih

Li, Jun Li, Jun

Rudolph, Sven

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Article abstract of DOI:10.1021/ol062715y

(Chemical Equation Presented) An efficient procedure for the directed reductive amination of β-hydroxy-ketones (3) for the stereoselective preparation of 1,3-syn-amino alcohols (6) is reported. The operationally simple protocol uses Ti(ⁱOPr) View More

Full text of DOI:10.1021/ol062715y

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