Efficient synthesis of N-protected amino/peptide Weinreb amides from T3P and DBU

DOI: 10.1016/j.tetlet.2012.11.064

Source and publish data:

Tetrahedron Letters p. 478 - 482 (2013)

Update date:2022-08-04

Topics:

Authors:

Sharnabai

Nagendra

Vishwanatha

Sureshbabu, Vommina V.

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Article abstract of DOI:10.1016/j.tetlet.2012.11.064

The reaction of N^α-protected amino/peptide acid with N,O-dimethylhydroxylamine hydrochloride in the presence of T3P and DBU to obtain enantiomerically pure N^α-protected amino/peptidyl Weinreb amides in high yields has been described. Fmoc-Ala-Weinreb amide 2a is obtained as single crystal, and its structure was determined through X-ray crystallography.

Full text of DOI:10.1016/j.tetlet.2012.11.064

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