Synthesis and biological activity of 5'-aminobenzoxazinorifamycin derivatives

DOI: 10.1248/cpb.40.2707

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2707 - 2711 (1992)

Update date:2022-08-04

Topics:

Authors:

Yamane Yamane

Hashizume

Yamashita

Hosoe Hosoe

Hidaka Hidaka

Watanabe

Kawaharada

Kudoh Kudoh

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Article abstract of DOI:10.1248/cpb.40.2707

Benzoxazinorifamycin reacted with various secondary amines to yield various 5'-substituted aminobenzoxazinorifamycin derivatives. The derivatives exhibited potent activities against gram-positive bacteria and mycobacteria. The antimicrobial activities of these compounds against Mycobacterium tuberculosis and Mycobacterium intracellulare were superior to those of rifampicin. Some of these compounds showed good plasma levels after oral administration in rats.

Full text of DOI:10.1248/cpb.40.2707

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