Synthesis and biological activity of 5'-aminobenzoxazinorifamycin derivatives

DOI: 10.1248/cpb.40.2707

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2707 - 2711 (1992)

Update date:2022-08-04

Topics:

Authors:

Yamane Yamane

Hashizume

Yamashita

Hosoe Hosoe

Hidaka Hidaka

Watanabe

Kawaharada

Kudoh Kudoh

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.2707

Benzoxazinorifamycin reacted with various secondary amines to yield various 5'-substituted aminobenzoxazinorifamycin derivatives. The derivatives exhibited potent activities against gram-positive bacteria and mycobacteria. The antimicrobial activities of these compounds against Mycobacterium tuberculosis and Mycobacterium intracellulare were superior to those of rifampicin. Some of these compounds showed good plasma levels after oral administration in rats.

Full text of DOI:10.1248/cpb.40.2707

NII-Electronic Library Service

Products guided by the article

Product name:(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-10-(diethylamino)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-1,6,15-trioxo-1,2-dihydro-6H,13H-2,7-(epoxypentadeca[1,11,13]trienoazeno)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate

Cas No:105396-16-5

R&D Labs maybe for 105396-16-5

SHANGHAI BIOSUNDRUG CO.,LTD.

Contact:86-21-34622192，13917187091，21-34622765

Address:No. 500 Caobao Road Shanghai P.R China
SHIFANG SUHONG CHEMICAL CO.,LTD

Contact:+86-838-2224563

Address:Room 1207 Zongchen Sunshine No.128 Taishan South Road,Deyang City,Sichuan China
Shijiazhuang Frontierchem Co., Ltd.

Contact:+86-311-89271196

Address:4-4-202 No.15 Biandian Street,Shijiazhuang
shijiazhuang alkay chemicals co..ltd(expird)

Contact:86-311-67692035

Address:2601,juntang building,qiaodong district,shijiazhuang
Hangzhou Sartort Biopharma Co., Ltd

website:http://www.sartort.com

Contact:86-571-87039693

Address:No. 57, Tech Park Road, Hangzhou, Zhejiang, China

Relevant to this article

γ-SILYLATED α,β-UNSATURATED AMIDES. FORMATION BY <1,5> SILICON MIGRATION FROM O-SILYLATED VINYL KETENE AMINALS AND FLUORIDE- AND LEWIS ACID-MEDIATED ALDOL CONDENSATIONS

Doi:10.1016/S0040-4039(00)84033-2
(1986)
Modular Synthesis of 4-aryl- and 4-amino-substituted benzene C-2′-Deoxyribonucleosides

Doi:10.1055/s-2008-1067038
(2008)
Crystal Structure and Coordination Chemistry of the Pentane-Soluble Sodium Salt of an Oxygen Tripod Ligand

Doi:10.1021/ja00235a025
(1987)
Doi:10.1021/ja01610a009
(1955)
Ligand properties of phosphinito platinum complexes: ³¹P and ¹⁹⁵Pt nuclear magnetic resonance studies and the crystal and molecular structure of [Cl(Et₃P)Pt(μ-PPh₂O)₂Pt(PEt₃)₂][BF₄]

Doi:10.1139/v86-314
(1986)
Convergent, regiospecific synthesis of quinolines from o- aminophenylboronates

Doi:10.1021/ol8016726
(2008)

Article Doi