A Novel Friedel-Crafts Type Reaction of 2-Chlorothiophene with Some Active Aromatic Compounds

Article abstract of DOI:10.1246/bcsj.59.83

2-Chlorothiophene (1) was found to easily react with certain active aromatic compounds (2) in the presence of AlCl3 under mild conditions, yielding the corresponding 2-arylthiophenes (3) and 5-chloro-2,2'-bithienyl (5) as the main products.With compounds more reactive than 1, the formation of 3 predominated.Reactions of 1 with aryl alkyl ethers, for example, afforded the corresponding 3 in 44-83percent yields in one step.