Synthesis of Potential Dual-Acting Radiation Sensitizer Antineoplastic Agents: 2,2-Dimethylphosphoraziridines Containing 2-Nitroimidazoles or Other Electron-Affinic Moieties

Article abstract of DOI:10.1021/jm00108a024

In view of the in vivo demonstrated radiation-potentiating activities of several previously studied 2,2-dimethylphosphoraziridines, six new compounds incorporating the bis(2,2-dimethyl-1-aziridinyl)phosphinyl moiety, together with an electron-affinic grou