Tetrahedron Letters p. 3491 - 3494 (1986)
Update date:2022-08-03
Topics:
Enders, Dieter
Papadopoulos, Kyriakos
Rendenbach, Beatrice E.M.
Appel, Rolf
Knoch, Falk
An efficient and highly anti-diastereo-(de=90-100percent) and enantioselective (ee=92-100percent) synthesis of 3,4-disubstituted 5-oxo-alkanoates 3 in good overall chemical yields is described.The procedure involves the asymmetric Michael addition of aldehydes or ketones to enoates via their lithiated SAMP-/RAMP-hydrazones.Both enantiomers are accessible at will.
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