Journal of Organic Chemistry p. 658 - 664 (1987)
Update date:2022-08-03
Topics:
Chi, Dae Yoon
Kilbourn, Michael R.
Katzenellenbogen, John A.
Welch, Michael J.
We have described a two-step method for the preparation of fluoroalkyl-substituted amines and amides.The sequence involves fluoride ion displacement of a haloalkyl trifluoromethanesulfonate (triflate), followed by fluoroalkylation of the heteroatom system (amine or amide) by the fluoroalkyl halide.Alternatively, the fluoroalkyl halide can be prepared by halofluorination of a terminal olefin.These reactions have been used to prepare various fluoroalkyl derivatives of N-phenylpiperazine and N-fluoroalkyl derivatives of the neuroleptic agent spiperone (7).The sequence is rapid, convenient, and efficient, even when fluoride ion is the limiting reagent.Therefore, it is readily adaptable to the preparation of a variety of compounds labeled with the short half-life (t1/2 = 110 min) positron-emitting radionuclide fluorine-18.
View MoreWuhan Hanye Chemical New Material Co.,Ltd
Contact:+86-27-85308141
Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
website:http://www.jairadhesales.com
Contact:0091-79-26431096
Address:309 Harikrupa Tower,Nr old Sharda Mandir Char Rasta,Ellisbridge
CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD
website:http://www.czyys.com
Contact:0086-519-88802789
Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China
Shanghai Dianyang Industry Co.,ltd
Contact:+86 21 6492 4669
Address:Chejing RD, Songjiang District, Shanghai, China
Contact:+86-531-58668191 58668193 58668196 58661173
Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
Doi:10.1016/j.tetasy.2008.06.018
(2008)Doi:10.1111/j.2042-7158.1953.tb13984.x
(1953)Doi:10.1080/15257770701528198
(2007)Doi:10.1021/ol801533p
(2008)Doi:10.1039/P19860000795
(1986)Doi:10.1021/ja01494a068
(1960)