Direct 4-Alkylation of 1,3-Cyclohexanediones via Dianionic Species

DOI: 10.1055/s-1986-31679

Source and publish data:

Synthesis p. 476 - 480 (1986)

Update date:2022-08-04

Topics:

Authors:

Berry, Nicola M.

Darey, Mark C. P.

Harwood, Laurence M.

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Article abstract of DOI:10.1055/s-1986-31679

1,3-Cyclohexanediones are directly alkylated at the 4 position via dianionic species generated at -78 deg C using lithium diisopropylamine/hexamethylphosphoric triamide.Acetylation of the reaction products at room temperature yields the 3-acetoxy-6-alkylc

Full text of DOI:10.1055/s-1986-31679

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