Preparation of 2,4-disubstituted cyclopentenones by enantioselective iridium-catalyzed allylic alkylation: Synthesis of 2′-methylcarbovir and TEI-9826

Article abstract of DOI:10.1002/chem.200800495

A broadly applicable synthesis of chiral 2- or 2,4-substituted cyclopent-2-enones has been developed by combining asymmetric iridium-catalyzed allylic alkylation reactions and ruthenium-catalyzed ring-closing meta-thesis. Enantiomeric excesses (ee values)