Catalytic asymmetric deprotonation of a phosphine borane: comparison of two-ligand and one-ligand catalysis

Article abstract of DOI:10.1016/j.tetasy.2009.10.002

The catalytic asymmetric deprotonation of tert-butyldimethylphosphine borane using s-BuLi or n-BuLi and sub-stoichiometric amounts of (-)-sparteine under one-ligand and two-ligand manifolds has been investigated. Using s-BuLi, slightly higher enantioselec