Asymmetric Reduction of Chiral Acetophenone Oxime Ethers to Optically Active Primary Amines

Article abstract of DOI:10.1246/cl.1986.1133

Chiral oxime ethers were synthesized from Na salt of acetophenone oxime and chiral halides, tosylates, or N-tosylaziridines which were derived from β-pinene or α-amino acids.Asymmetric reduction of the chiral oxime ether with LiAlH4 or BH3*THF gave the optically active primary amine.