Regioselective Functionalization of Pyridinesulfonic Acids. Ortho-Lithiation of Tertiary 2- and 4-Pyridinesulfonamides

DOI: 10.1021/jo00382a029

Source and publish data:

Journal of Organic Chemistry p. 1133 - 1136 (1987)

Update date:2022-08-04

Topics: Functionalization Tertiary Regioselective Ortho-lithiation

Authors:

Marsais, F.

Cronnier, A.

Trecourt, F.

Queguiner, G.

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Article abstract of DOI:10.1021/jo00382a029

Tertiary 2- and 4-pyridinesulfonamides were ortho-lithiated at low temperature by an excess of lithium diisopropylamide.Proton abstraction occurs selectively at the more acid 3-positions in the two cases. 3-Lithio-2- and -4-(piperidinosulfonyl)pyridines r

Full text of DOI:10.1021/jo00382a029

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