Synthesis of a spiroacetal moiety of antitumor antibiotic ossamycin by anodic oxidation

DOI: 10.1016/j.tet.2008.07.078

Source and publish data:

Tetrahedron p. 9495 - 9506 (2008)

Update date:2022-08-04

Topics:

Authors:

Honjo, Eriko

Kutsumura, Noriki

Ishikawa, Yuichi

Nishiyama, Shigeru

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Article abstract of DOI:10.1016/j.tet.2008.07.078

Synthesis of the spiroacetal moiety (C20-C33) of the antitumor antibiotic ossamycin, is reported. Anodic oxidation of the dithioacetal effected simultaneous removal of the protecting group and acetalization to afford the corresponding 6,6-spiroacetal structure in excellent yield.

Full text of DOI:10.1016/j.tet.2008.07.078

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