Bioorganic and Medicinal Chemistry p. 5099 - 5117 (2018)
Update date:2022-08-05
Topics:
Shinozuka, Tsuyoshi
Tsukada, Tomoharu
Fujii, Kunihiko
Tokumaru, Eri
Shimada, Kousei
Onishi, Yoshiyuki
Matsui, Yumi
Wakimoto, Satoko
Kuroha, Masanori
Ogata, Tsuneaki
Araki, Kazushi
Ohsumi, Jun
Sawamura, Ryoko
Watanabe, Nobuaki
Yamamoto, Hideki
Fujimoto, Kazunori
Tani, Yoshiro
Mori, Makoto
Tanaka, Jun
Attempts were made to reduce the lipophilicity of previously synthesized compound (II) for the avoidance of hepatotoxicity. The replacement of the left-hand side benzene with 2-pyridine resulted in the substantial loss of potency. Because poor membrane pe
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