Bioorganic and Medicinal Chemistry Letters p. 55 - 58 (1999)
Update date:2022-07-29
Topics:
Confalone, Pat N.
Fuqiang, Jin
Mousa, Shaker A.
A series of isoxazolidines has been synthesized as mimetics of the RGD sequence and was evaluated as antagonists of the platelet glycoprotein IIb/IIIa receptor. These compounds were shown to be highly potent GPIIb/IIIa antagonists, exhibiting submicromolar potencies.
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