Journal of Organic Chemistry p. 12639 - 12647 (2019)
Update date:2022-07-29
Chen, Zhengwang
Liang, Pei
Xu, Fan
Deng, Zhen
Long, Lipeng
Luo, Guotian
Ye, Min
A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C-C/C-N/C-S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields.
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