Isozyme-Specific Enzyme Inhibitors. 13. S-adenosyl>-L-homocysteine, a Potent Inhibitor of Rat Methionine Adenosyltranferases

DOI: 10.1021/jm00388a024

Source and publish data:

Journal of Medicinal Chemistry p. 888 - 894 (1987)

Update date:2022-08-05

Topics:

Authors:

Vrudhula, Vivekananda M.

Kappler, Francis

Hampton, Alexander

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Article abstract of DOI:10.1021/jm00388a024

A synthesis is described of the title compound and its 5'S epimer, which are two-substrate adducts of adenosine 5'-triphosphate (ATP) and L-methionine (Met) in which the C(5')H2OP system in ATP is replaced by CH(R)CH2NHP .The 5'R e

Full text of DOI:10.1021/jm00388a024

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