Journal of Organic Chemistry p. 2051 - 2059 (1987)
Update date:2022-07-30
Topics: Yield NMR spectroscopy Mass spectrometry (MS) Cyclization HPLC (high-performance liquid chromatography) Protecting group Carboxylic acid Purification Reaction Monitoring Solid-Phase Peptide Synthesis (SPPS) Hydrophobicity Solvent Evaporation Heterocyclic compound Amide bond Tetrazole Bioisostere Melting Point Determination
Yu, Kuo-Long
Johnson, Rodney L.
Tetrazole dipeptide analogues in which the amide bond is replaced with the tetrazole ring were synthesized from the corresponding Z or Pht protected dipeptide esters via the imidoyl chloride and imidoyl azide intermediates.Of the various imidoyl chloride/
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