Journal of Organic Chemistry p. 10256 - 10265 (2016)
Update date:2022-07-29
Topics:
Kuethe, Jeffrey T.
Humphrey, Guy R.
Journet, Michel
Peng, Zhihui
Childers, Karla G.
The development of a practical asymmetric total synthesis of the potent HIV-1 integrase inhibitor 5 is described. Key transformations include construction of the naphthridine core in a highly efficient manner followed by cyclization of the 8-membered ring. Control of the atropisomers of intermediates and final compound 5 is also described.
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