Nucleophilic Addition of the Pentafluoroethyl Group to Aldehydes, Ketones, and Esters

DOI: 10.1021/jo00388a025

Source and publish data:

Journal of Organic Chemistry p. 2481 - 2490 (1987)

Update date:2022-07-29

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Authors:

Gassman, Paul G.

O'Reilly, Neil J.

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Article abstract of DOI:10.1021/jo00388a025

Pentafluoroethyl iodide reacts with methyllithium at -78 deg C to produce (pentafluoroethyl)lithium.This halogen-metal exchange reaction can be carried out in the presence of aldehydes, ketones, and esters with no observable addition of methyllithium to t

Full text of DOI:10.1021/jo00388a025

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