Determination of cephalosporins and decomposition products by liquid chromatography with indirect electrochemical detection

Article abstract of DOI:10.1021/ac00153a008

Indirect electrochemical detection, using in-line electrochemically generated bromine as oxidizing agent, has been used for the determination of cephalosporins with liquid chromatography. The method presents a general detection principle for cephalosporins since it is related to their basic structure. The detection limits obtained, which were between 0. 4 and 3 ng, and the repeatability with a relative standard deviation below 1. 5% comply with the requirements for drug stability studies in vitro.