2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) Derivatives as α1-Adrenoceptor Antagonists and Antihypertensive Agents

DOI: 10.1021/jm00389a007

Source and publish data:

Journal of Medicinal Chemistry p. 999 - 1003 (1987)

Update date:2022-09-26

Topics:

Authors:

Alabaster, Valerie A.

Campbell, Simon F.

Danilewicz, John C.

Greengrass, Colin W.

Plews, Rhona M.

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Article abstract of DOI:10.1021/jm00389a007

A series of 4-amino-2-(4-carbamoylpiperidino)-6,7-dimethoxyquinazolines (2) were synthesized and evaluated for α-adrenoceptor affinity and antihypertensive activity.These compounds displayed high binding affinity (K_i, 10^-9-10^-10

Full text of DOI:10.1021/jm00389a007

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