2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) Derivatives as α1-Adrenoceptor Antagonists and Antihypertensive Agents

DOI: 10.1021/jm00389a007

Source and publish data:

Journal of Medicinal Chemistry p. 999 - 1003 (1987)

Update date:2022-09-26

Topics:

Authors:

Alabaster, Valerie A.

Campbell, Simon F.

Danilewicz, John C.

Greengrass, Colin W.

Plews, Rhona M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00389a007

A series of 4-amino-2-(4-carbamoylpiperidino)-6,7-dimethoxyquinazolines (2) were synthesized and evaluated for α-adrenoceptor affinity and antihypertensive activity.These compounds displayed high binding affinity (K_i, 10^-9-10^-10

Full text of DOI:10.1021/jm00389a007

Products guided by the article

Product name:4-Piperidinecarboxamide, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-phenyl-

Cas No:108297-14-9

R&D Labs maybe for 108297-14-9

Taizhou Huading Chemical Co.,Ltd(expird)

Contact:+86-576-88583898

Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Allicon Pharmaceuticals,Inc.

Contact:+86-519-86339586，13584329896

Address:Changzhou Scientific and Education Park
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)

Contact:051989185693

Address:NO 217 huangshan Rd ,Changzhou
Taizhou Sunny Chemical Co.,Ltd

Contact:+86-523-86920899 +86-13951172783

Address:No.11 Xingyuang road, Gaoyong Chemical Industry Park, Gaogang Jiangsu China
Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province

Relevant to this article

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

Doi:10.1021/acs.jmedchem.5b00963
(2015)
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3,3'-BIS-(PROPYN-1,1'-BENZOATO)DIMETHYLSILANES

Doi:10.1007/BF00772941
(1992)
Total synthesis of dictyodendrins B and e

Doi:10.1021/jo400841d
(2013)
Bioorganic hybrid OMS by straightforward grafting of trialkoxysilyl peptides

Doi:10.1039/c3tb20122h
(2013)
Novel Synthesis of 2-Pphosphinoylphospholane 1-Oxide Derivatives

Doi:10.1246/bcsj.65.2004
(1992)
SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING 4-N-(ω-AMINOHEXYL)-5-METHYLDEOXYCYTIDINE

Doi:10.1007/BF00630367
(1991)

Article Doi