2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) Derivatives as α1-Adrenoceptor Antagonists and Antihypertensive Agents

DOI: 10.1021/jm00389a007

Source and publish data:

Journal of Medicinal Chemistry p. 999 - 1003 (1987)

Update date:2022-09-26

Topics:

Authors:

Alabaster, Valerie A.

Campbell, Simon F.

Danilewicz, John C.

Greengrass, Colin W.

Plews, Rhona M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00389a007

A series of 4-amino-2-(4-carbamoylpiperidino)-6,7-dimethoxyquinazolines (2) were synthesized and evaluated for α-adrenoceptor affinity and antihypertensive activity.These compounds displayed high binding affinity (K_i, 10^-9-10^-10

Full text of DOI:10.1021/jm00389a007

Products guided by the article

Product name:4-Piperidinecarboxamide, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-phenyl-

Cas No:108297-14-9

R&D Labs maybe for 108297-14-9

Clearsynth Labs Limited

Contact:+91 - 22 - 26355700

Address:17, Lotus Business Park, Andheri West
Zhejiang Sucon Silicone Co.,Ltd

Contact:+86-575-88046692

Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.
Chinese Peptide Company

Contact:86-571-86737118-8689

Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Hubei Lingsheng Pharmaceuticals Co., Ltd.

Contact:+86-0710-3538058

Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
YingYing Pharmaceutical Co.,Ltd

Contact:86-18854126208

Address:55#, yingxiongshan road

Relevant to this article

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

Doi:10.1021/acs.jmedchem.5b00963
(2015)
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3,3'-BIS-(PROPYN-1,1'-BENZOATO)DIMETHYLSILANES

Doi:10.1007/BF00772941
(1992)
Total synthesis of dictyodendrins B and e

Doi:10.1021/jo400841d
(2013)
Bioorganic hybrid OMS by straightforward grafting of trialkoxysilyl peptides

Doi:10.1039/c3tb20122h
(2013)
Novel Synthesis of 2-Pphosphinoylphospholane 1-Oxide Derivatives

Doi:10.1246/bcsj.65.2004
(1992)
SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING 4-N-(ω-AMINOHEXYL)-5-METHYLDEOXYCYTIDINE

Doi:10.1007/BF00630367
(1991)

Article Doi