Organic Letters p. 2115 - 2118 (2003)
Update date:2022-07-29
Topics: Cyclization Biological testing Purification and characterization Side Chain Functionalization Library Generation Design and Planning Coupling reactions
Jimenez, Jose C.
Chavarria, Bibiana
Lopez-Macia, Angel
Royo, Miriam
Giralt, Ernest
Albericio, Fernando
(Matrix presented) A solid-phase method for the synthesis of tentoxin has been developed. Two key steps - dehydration and N-alkylation - are carried out while the peptide is anchored to the resin. The method, which has been validated by the preparation of
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Doi:10.1021/ja00249a017
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