Anionic-anionic asymmetric tandem reactions: One-pot synthesis of optically pure fluorinated indolines from 2-p-tolylsulfinyl alkylbenzenes

Article abstract of DOI:10.1002/anie.200802885

Chirality switch up: A novel strategy has been developed to give optically pure fluorinated indolines with one or two stereogenic centers (see scheme; A_N = nucleophilic addition, PG = protecting group, S_NAr = intramolecular nucleophilic aromatic substitution, Tol = tolyl). Almost complete stereoselectivity and mild reaction conditions are the key features of the title reaction. (Chemical Equation Presented)