European Journal of Medicinal Chemistry p. 2535 - 2540 (2008)
Update date:2022-07-30
Topics:
Catalano, Alessia
Carocci, Alessia
Corbo, Filomena
Franchini, Carlo
Muraglia, Marilena
Scilimati, Antonio
De Bellis, Michela
De Luca, Annamaria
Camerino, Diana Conte
Sinicropi, Maria Stefania
Tortorella, Vincenzo
1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two conformationally restricted analogues of tocainide, were designed and synthesized as voltage-gated skeletal muscle sodium channel blockers. They showed, with respect to tocainide, a marked increase in both potency and use-dependent block.
website:http://www.shtopchem.com/
Contact:0086-0576-87776998
Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Contact:+86-158-05817090
Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
website:http://www.antaibio.com
Contact:0086-21-65663057
Address:Room 2108, Building 2，No. 489 Zhengli Road，200433
Suzhou Chiral Pharmaceuticals Co., Ltd.
Contact:86-0512-63197058
Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
ShanDong XinDa Chemical CO.,LTD(expird)
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
Doi:10.1016/j.bmc.2008.10.009
(2008)Doi:10.1039/c9cc09595k
(2020)Doi:10.1021/om400811z
(2014)Doi:10.1021/ja01585a026
()Doi:10.1016/j.tetlet.2008.09.164
(2008)Doi:10.1021/ol802638k
(2009)
