European Journal of Medicinal Chemistry p. 2535 - 2540 (2008)
Update date:2022-07-30
Topics:
Catalano, Alessia
Carocci, Alessia
Corbo, Filomena
Franchini, Carlo
Muraglia, Marilena
Scilimati, Antonio
De Bellis, Michela
De Luca, Annamaria
Camerino, Diana Conte
Sinicropi, Maria Stefania
Tortorella, Vincenzo
1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two conformationally restricted analogues of tocainide, were designed and synthesized as voltage-gated skeletal muscle sodium channel blockers. They showed, with respect to tocainide, a marked increase in both potency and use-dependent block.
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Doi:10.1016/j.bmc.2008.10.009
(2008)Doi:10.1039/c9cc09595k
(2020)Doi:10.1021/om400811z
(2014)Doi:10.1021/ja01585a026
()Doi:10.1016/j.tetlet.2008.09.164
(2008)Doi:10.1021/ol802638k
(2009)
