
Bulletin of the Chemical Society of Japan p. 2353 - 2355 (1986)
Update date:2022-08-04
Topics:
Duhamel, Pierre
Kotera, Mitsuharu
Monteil, Thierry
The 2,2-bifunctionalized piperidines 6 and 10 were obtained via ring contraction of the seven-membered heterocyclic enamino aldehyde 5 in nearly quantitative yield.The synthesis of 1-benzyl-1-azaspiro<5.5>undec-7-en-9-one 9 (a formal precursor or perhydrohistrionicotoxin 1b) in 3 steps from the piperidinedialdehyde monoacetal 6, is reported.
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