Novel irreversible ligands specific for 'peripheral' type benzodiazepine receptors: (±)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1 methylpropyl)-N-(2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlor

DOI: 10.1021/jm00393a036

Source and publish data:

Journal of Medicinal Chemistry p. 1901 - 1905 (1987)

Update date:2022-08-03

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Authors:

Newman Newman

Lueddens

Skolnick

Rice Rice

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Article abstract of DOI:10.1021/jm00393a036

Novel ligands that bind irreversibly and selectively to 'peripheral' type benzodiazepine receptors (PBR) have been prepared. These compounds inhibits radiolabeled binding to PBR in the nanomolar range. The 2-isothiocyanatoethyl analogue of Ro 5-4864 (1-me

Full text of DOI:10.1021/jm00393a036

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