Novel irreversible ligands specific for 'peripheral' type benzodiazepine receptors: (±)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1 methylpropyl)-N-(2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlor

DOI: 10.1021/jm00393a036

Source and publish data:

Journal of Medicinal Chemistry p. 1901 - 1905 (1987)

Update date:2022-08-03

Topics:

Authors:

Newman Newman

Lueddens

Skolnick

Rice Rice

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00393a036

Novel ligands that bind irreversibly and selectively to 'peripheral' type benzodiazepine receptors (PBR) have been prepared. These compounds inhibits radiolabeled binding to PBR in the nanomolar range. The 2-isothiocyanatoethyl analogue of Ro 5-4864 (1-me

Full text of DOI:10.1021/jm00393a036

Products guided by the article

Product name:(+/-)-N-carbobenzoxy-2-<(1-methylpropyl)amino>ethylamine

Cas No:109960-08-9

R&D Labs maybe for 109960-08-9

Dayang Chem (Hangzhou) Co.,Ltd.

website:http://www.dycnchem.com

Contact:+86-571-88938639

Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China
Fuxin Jintelai Fluorin Chemical Co., Ltd.

Contact:+86-0418-8229599

Address:, 7th Huagong Road, Fluorine industry development zone (Yimatu Town,Fumeng County),Fuxin City, Liaoning Province, China
Jiangsu Taihu New Materials Holding Co., Ltd

Contact:+86-519-86160108

Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China
Acorn PharmaTech Co., Ltd

Contact:86-25-58619180

Address:Nanjing High-Tech Zone 10 Xinghuo Road Pukou District Nanjing, Jiangsu 210061 The People's Republic of China
Anhui Qingyun Pharmaceutical and Chemical Co.,Ltd

Contact:+86-551-63633067

Address:Shuangfeng Road Hefei Anhui

Relevant to this article

Modulation of PPAR receptor subtype selectivity of the ligands: Aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety

Doi:10.1016/j.bmcl.2008.10.062
(2008)
LIGNAN GLYCOSIDES FROM PARSONSIA LAEVIGATA

Doi:10.1016/S0031-9422(00)97835-X
(1989)
Doi:10.1021/jm00298a020
(1970)
SYNTHESIS OF BOTH ENANTIOMERIC FORMS OF 2-SUBSTITUTED 1,3-PROPANEDIOL MONOACETATES STARTING FROM A COMMON PROCHIRAL PRECURSOR, USING ENZYMATIC TRANSFORMATIONS IN AQUEOUS AND IN ORGANIC MEDIA

Doi:10.1016/S0040-4039(00)85306-X
(1986)
Asymmetrie synthesis of 3-amino-δ-lactams and benzo [a] quinolizidines by catalytic cyclization reactions involving azlactones

Doi:10.1002/chem.200900814
(2009)
A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives

Doi:10.1016/j.bmcl.2008.10.045
(2008)

Article Doi