A DIRECT SYNTHESIS OF TRANS 2-ARYLBENZOCYCLOBUTENOL, A POTENTIAL INTERMEDIATE FOR PODOPHYLLOTOXIN SYNTHESIS: USE OF LDA FOR BENZYNE FORMATION AND TRAPPING

DOI: 10.1016/S0040-4039(00)85200-4

Source and publish data:

Tetrahedron Letters p. 5319 - 5322 (1986)

Update date:2022-08-03

Topics:

Authors:

Jung, Michael E.

Lowen, Gregory T.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)85200-4

Treatment of m-alkoxyaryl bromides with LDA in THF produces the corresponding aryne which can be trapped intramolecularly by an anion α to a nitrile to produce a substituted benzocyclobutenyl nitrile, the precursor of a trans arylbenzocyclobutenol potenti

Full text of DOI:10.1016/S0040-4039(00)85200-4

Products guided by the article

Product name:3-(6-Bromo-benzo[1,3]dioxol-5-yl)-2-cyano-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester

Cas No:110087-29-1

R&D Labs maybe for 110087-29-1

HANGZHOU FOREWIN PHARMA CO., LTD

Contact:+86-571-89053961

Address:hangzhou
HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Contact:+86-186-02659358

Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China
shandong zhongke taidou chemical co.,ltd

Contact:86-531-88682301

Address:Jinan shandong Province CHina
Zhengzhou Minzhong Pharmaceutical Co.,ltd

Contact:0086-371-65797115

Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Lalpharm Co., Ltd.,

Contact:+8613581984929

Address:Beijing

Relevant to this article

A new route to thiopyran S,S-dioxide derivatives via an overall ring-enlargement protocol from 3-nitrothiophene

Doi:10.1016/j.tet.2008.10.046
(2009)
3-Acyl-1,3-diaryltriazenes as neutral and selective acylating agents

Doi:10.1016/S0040-4039(01)01358-2
(2001)
An efficient and convenient synthesis of deuterium-labelled seminolipid isotopomers and their ESI-MS characterization

Doi:10.1016/j.chemphyslip.2008.02.002
(2008)
Unusual radical 6-endo cyclization to carbocyclic-ENA and elucidation of its solution conformation by 600 MHz NMR and ab initio calculations

Doi:10.1039/b813870b
(2008)
Thermal Rearrangements of 3H- and 4H-Pyrazoles Prepared by Reactions of 9-Diazofluoren with Methyl Tetrolate and Methyl 3-Phenylpropiolate

Doi:10.1134/S1070428018080122
(2018)
Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship

Doi:10.1016/j.bmcl.2011.05.041
(2011)

Article Doi