Bioorganic and Medicinal Chemistry Letters p. 3871 - 3876 (2011)
Update date:2022-08-03
Topics:
Macsari, Istvan
Sandberg, Lars
Besidski, Yevgeni
Gravenfors, Ylva
Ginman, Tobias
Bylund, Johan
Bueters, Tjerk
Eriksson, Anders B.
Lund, Per-Eric
Venyike, Elisabet
Arvidsson, Per I.
Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective NaV1.7 blocker. Structural analogues of 1, both carbamates,
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