A Building Block for the Sequence-Specific Introduction of Cis-Syn Thymine Dimers into Oligonucleotides. Solid-Phase Synthesis of TpTpTpT

DOI: 10.1021/ja00256a030

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Journal of the American Chemical Society p. 6735 - 6742 (1987)

Update date:2022-07-30

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Authors:

Taylor, John-Stephen

Brockie, Ian R.

O'Day, Christine L.

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Article abstract of DOI:10.1021/ja00256a030

We report the synthesis of a synthetic intermediate for the sequemce specific incorporation of the cis-syn thymine dimer into oligonucleotides via phosphoramidite-based solid-phase DNA synthesis technology.The required phosphoramidite 1a was obtained in f

Full text of DOI:10.1021/ja00256a030

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