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Synthesis and antibacterial activities of 13-bis[3-N-acetyl-2-aryl-1,3,4- oxadiazoline-5-yl]benzenes

DOI: 10.1515/HC.2008.14.1-2.101

Source and publish data:

Heterocyclic Communications p. 101 - 105 (2008)

Update date:2022-08-05

Topics:

Authors:

Li, De-JiangLi, De-Jiang

Dan, Fei-JunDan, Fei-Jun

Fu, He-QingFu, He-Qing

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Article abstract of DOI:10.1515/HC.2008.14.1-2.101

Dimethyl isophthalate (1) was reacted with 80% hydrazine hydrate in refluxing ethanol for 16 h to give isophthalic dihydrazide (2). Condensation of 2 with aromatic aldehydes afforded corresponding hydrazones 3a-3i. Cyclization of 3a-3i with acetic anhydride in refluxing for 4-5 h afforded 1,3-Bis[3-N-acetyl-2-aryl-1,3,4-oxadiazoline-5-yl]benzenes (4a-4i). The structures of 4a-4i were characterized by elementary analyses, IR, 1H NMR, and MS spectroscopy. The preliminary antibacterial tests showed that most of them were effective against S.aureus.

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Full text of DOI:10.1515/HC.2008.14.1-2.101

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Download Date | 5/31/15 3:30 AM  
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