
Heterocyclic Communications p. 101 - 105 (2008)
Update date:2022-08-05
Topics:
Li, De-Jiang
Dan, Fei-Jun
Fu, He-Qing
Dimethyl isophthalate (1) was reacted with 80% hydrazine hydrate in refluxing ethanol for 16 h to give isophthalic dihydrazide (2). Condensation of 2 with aromatic aldehydes afforded corresponding hydrazones 3a-3i. Cyclization of 3a-3i with acetic anhydride in refluxing for 4-5 h afforded 1,3-Bis[3-N-acetyl-2-aryl-1,3,4-oxadiazoline-5-yl]benzenes (4a-4i). The structures of 4a-4i were characterized by elementary analyses, IR, 1H NMR, and MS spectroscopy. The preliminary antibacterial tests showed that most of them were effective against S.aureus.
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