Synthesis of 9(0)-methano-Δ6(9α)-PGI1: The highly potent carbon analog of prostacyclin

DOI: 10.1016/S0040-4039(00)86021-9

Source and publish data:

Tetrahedron Letters p. 3493 - 3496 (1983)

Update date:2022-08-02

Topics:

Authors:

Shibasaki

Torisawa

Ikegami Ikegami

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Article abstract of DOI:10.1016/S0040-4039(00)86021-9

A new prostacyclin analog, 9(o)-methano-Δ⁶(9α)-PGI₁, was synthesized by utilizing intramolecular pinacolic coupling reaction as the key step and was shown to be more potent than carbacyclin in inhibition of platelet aggregation.

Full text of DOI:10.1016/S0040-4039(00)86021-9

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