Journal of Organic Chemistry p. 5601 - 5605 (1987)
Update date:2022-09-26
Topics:
Vyas, D. M.
Chiang, Y.
Benigni, D.
Doyle, T. W.
Reactions of formamide acetals (e.g.DMFDMA, 10, 12) with mitomycin C (1) has afforded novel amidine derivatives (e.g. 7-9, 11, 13).Investigation of reactions of amines with bisamidine 8 in both polar and nonpolar solvents (e.g.MeOH vs CHCl3) has led to the discovery that 8, in its reactions with primary amines in methanol, behaves as a mitomycin A (2) equivalent to afford 7-N-substituted mitosanes (e.g. 16-19).In contrast, bisamidine 8 undergoes a selective deamidination reaction with primary amines in chloroform to afford monoamidine 14.
View MoreContact:0792-8228321
Address:10TH Floor No.121 binjiang Road Xunyang District
HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.
Contact:+86-186-02659358
Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China
Daicel Chiral Technologies (China)CO.,LTD
Contact:021-5046-0086*8
Address:Part C, FL 5, the 16th Building, No. 69, XiYa Road, WaiGaoQiao Free Trade Zone, Shanghai, 200131, P.R.China
Contact:86-10-62983737; +86-10-51287608
Address:4/F Building C, 2 Shangdi Xinxi Road
Contact:+86-571-28186845
Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China
Doi:10.1055/s-2002-32607
(2002)Doi:10.1021/jo0508898
(2005)Doi:10.1021/ol5027798
(2014)Doi:10.1021/jo01115a613
(1956)Doi:10.1021/ac00152a013
(1988)Doi:10.4314/bcse.v29i2.14
(2015)
