Catechol based inhibitors of 15-lipoxygenase

DOI: 10.1016/0960-894X(95)00565-B

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 93 - 96 (1996)

Update date:2022-09-26

Topics:

Authors:

Tait, Bradley D.

Dyer, Richard D.

Auerbach, Bruce J.

Bornemeier, Dirk

Guilds-Zamarka, Linda

Oxender, Maritza

Roth, Bruce D.

Trivedi, Bharat K.

Cornicelli, Joseph A.

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Article abstract of DOI:10.1016/0960-894X(95)00565-B

A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.

Full text of DOI:10.1016/0960-894X(95)00565-B

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