Bioorganic and Medicinal Chemistry Letters p. 93 - 96 (1996)
Update date:2022-09-26
Topics:
Tait, Bradley D.
Dyer, Richard D.
Auerbach, Bruce J.
Bornemeier, Dirk
Guilds-Zamarka, Linda
Oxender, Maritza
Roth, Bruce D.
Trivedi, Bharat K.
Cornicelli, Joseph A.
A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.
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