The Synthesis and Cycloaddition Reactions of 3-Azabicyclohex-2-ene 3-oxide and 3-Azabicyclohept-2-ene 3-oxide. Highly Strained Bicyclic Nitrones

DOI: 10.1016/S0040-4039(00)95703-4

Source and publish data:

Tetrahedron Letters p. 267 - 270 (1987)

Update date:2022-07-31

Topics: Synthesis IR spectroscopy Regioselectivity Column chromatography NMR spectroscopy Mass spectrometry Recrystallization Dipolarophile TLC (thin-layer chromatography) Stereoselectivity Cycloaddition Reaction Optimization 1,3-Dipolar Cycloaddition Ring Strain Reaction yield Nitrone N-oxide 3-Azabicyclo[3

Authors:

Tufariello, Joseph J.

Milowsky, Arnold S.

Al-Nuri, Mohammed

Goldstein, Steven

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Article abstract of DOI:10.1016/S0040-4039(00)95703-4

The synthesis of two strained bicyclic nitrones is described.Subsequent cycloadditions demonstrated a high degree of regiochemical and stereochemical control.

Full text of DOI:10.1016/S0040-4039(00)95703-4

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