Synthesis of the Phosphodiesterase Inhibitors PDE-I and PDE-II

DOI: 10.1039/c39850001775

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1775 - 1776 (1985)

Update date:2022-07-29

Topics: Synthesis Inhibitors Phosphodiesterase

Authors:

Bolton, Richard E.

Moody, Christopher J.

Rees, Charles W.

Tojo, Gabriel

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Article abstract of DOI:10.1039/c39850001775

The pyrrolo<3,2-e>indole phosphodiesterase inhibitors PDE-I (1) and PDE-II (2) have been synthesised from isovanilin by a route which involves construction of both pyrrole rings by thermolysis of azidoacrylates readily derived from benzaldehydes.

Full text of DOI:10.1039/c39850001775

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Product name:benzyl 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

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