Synthesis of the Phosphodiesterase Inhibitors PDE-I and PDE-II

DOI: 10.1039/c39850001775

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1775 - 1776 (1985)

Update date:2022-07-29

Topics: Synthesis Inhibitors Phosphodiesterase

Authors:

Bolton, Richard E.

Moody, Christopher J.

Rees, Charles W.

Tojo, Gabriel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39850001775

The pyrrolo<3,2-e>indole phosphodiesterase inhibitors PDE-I (1) and PDE-II (2) have been synthesised from isovanilin by a route which involves construction of both pyrrole rings by thermolysis of azidoacrylates readily derived from benzaldehydes.

Full text of DOI:10.1039/c39850001775

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:benzyl 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

Cas No:112014-71-8

R&D Labs maybe for 112014-71-8

Arshine Pharmaceutical Co., Limited

website:http://www.cnarshine.com

Contact:0731-88503671

Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
Guarson Chemical Co., Ltd.

website:http://www.guarson.com

Contact:+86-523-88059600,+86-13805268803

Address:Room B1006,Yafang Building,Jiangyan Avenue,Jiangyan District, Taizhou City,Jiangsu,China
Quzhou Ruiyuan chemical Co., Ltd

Contact:+86-570-3039321/3039361/3039308

Address:18# Huayang Road,Quzhou High-tech Industrial Park, Zhejiang China.
Luzhou North Chemical Co., Ltd.

Contact:+86-830-2796784；+86-830-2796776

Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
Jinan Boss Chemical Industry Co., Ltd.【revoke the business license】

website:http://www.chemboss.com.cn

Contact:+86-531-58591595

Address:No2.Hualong Road, Jinan, China

Relevant to this article

New synthetic routes for 1-benzyl-1,4,7,10-tetraazacyclododecane and 1,4,7,10-tetraazacyclododecane-1-acetic acid ethyl ester, important starting materials for metal-coded DOTA-based affinity tags

Doi:10.1515/znb-2007-0313
(2007)
Organocatalytic asymmetric α-aminoxylation/aza-michael reactions for the synthesis of functionalized tetrahydro-1,2-oxazines

Doi:10.1002/anie.200803731
(2008)
A Synthesis of (3S,4R)-3-<(R)-1-(t-Butyldimethylsilyloxy)ethyl>-4-carboxymethyl-2-azetidinone, the Thienamycin Intermadiate, from (S)-Ethyl Lactate

Doi:10.1246/cl.1987.445
(1987)
Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors

Doi:10.1021/jm800499x
(2008)
Catalytic asymmetric aminoallylation of aldehydes: A catalytic enantioselective aza-cope rearrangement

Doi:10.1002/anie.200803610
(2008)
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein–Protein Interactions

Doi:10.1002/anie.201916257
(2020)

Article Doi