Highly Selective Methods for α-Alkenylation and α-Arylation of Ketones via Palladium- or Nickel-Catalyzed Cross Coupling

DOI: 10.1246/cl.1987.1007

Source and publish data:

Chemistry Letters p. 1007 - 1010 (1987)

Update date:2022-08-05

Topics:

Authors:

Negishi, Ei-ichi

Akiyoshi, Kazunari

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Article abstract of DOI:10.1246/cl.1987.1007

Two procedures for α-alkenylation and α-arylation of ketones, that permit, for the first time, introduction of a stereo-defined alkenyl group (E or Z) in the α-position of cyclic ketones in high yields with essentially complete retention (>98percent) of the alkenyl stereochemistry are reported.Furthermore, the one that is represented by Eq.2 permits complete control of regiochemistry as well.

Full text of DOI:10.1246/cl.1987.1007

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