Highly Selective Methods for α-Alkenylation and α-Arylation of Ketones via Palladium- or Nickel-Catalyzed Cross Coupling

Article abstract of DOI:10.1246/cl.1987.1007

Two procedures for α-alkenylation and α-arylation of ketones, that permit, for the first time, introduction of a stereo-defined alkenyl group (E or Z) in the α-position of cyclic ketones in high yields with essentially complete retention (>98percent) of the alkenyl stereochemistry are reported.Furthermore, the one that is represented by Eq.2 permits complete control of regiochemistry as well.