Journal of Medicinal Chemistry p. 590 - 603 (1988)
Update date:2022-08-05
Topics: Molecular modeling Biological Activity Spectroscopic Analysis DNA Interaction Experimental Design CC-1065 stereoelectronic factors Quantitative structure-activity relationship (QSAR)
Warpehoski
Gebhard
Kelly
Krueger
Li
McGovren
Prairie
Wicnienski
Wierenga
The synthesis, physicochemical properties, and biological activities of a series of novel spiro cyclopropyl compounds, modeled on the potent antitumor antibiotic CC-1065 (1), are described. Many of these synthetic analogues are significantly more effectiv
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