Etoposide: a new approach to the synthesis of 4-O-(2-amino-2-deoxy-4,6-O-ethylidene-β-D-glucopyranosyl)-4'-O-demethyl-4-epipodophyllotoxin

Article abstract of DOI:10.1016/0008-6215(90)80062-8

Synthesis of 3-O-acetyl-2-benzyloxycarbonylamino-2-deoxy-4,6-O-ethylidene-α-(7α) and -β-D-glucopyranose (7β) and their 3-O-chloroacetyl analogues (11α and 11β) are described.Condensation (BF3-etherate, ethyl acetate, -20 deg C) of 7α with 4'-O-benzyloxyca