PREPARATION OF t-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

Article abstract of DOI:10.1016/S0040-4039(00)95725-3

The preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate (1) and Wadsworth- Emmons reaction with aldehydes and ketones is reported.Some of the products of these reactions were converted to unsaturated 3-oxomacrolides or 3-oxodiolides by transester