
Bioorganic and Medicinal Chemistry Letters p. 397 - 400 (2009)
Update date:2022-08-03
Topics:
Porter, John
Lumb, Simon
Lecomte, Fabien
Reuberson, James
Foley, Anne
Calmiano, Mark
le Riche, Kelly
Edwards, Helen
Delgado, Jean
Franklin, Richard J.
Gascon-Simorte, Jose M.
Maloney, Alison
Meier, Christoph
Batchelor, Mark
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the
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