Potential Antitumor Agents. 55. 6-Phenylphenanthridine-4-carboxamides: A New Class of DNA-Intercalating Antitumor Agents

DOI: 10.1021/jm00399a015

Source and publish data:

Journal of Medicinal Chemistry p. 774 - 779 (1988)

Update date:2022-09-26

Topics:

Authors:

Atwell, Graham J.

Baguley, Bruce C.

Denny, William A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00399a015

Derivatives of the DNA-intercalating agent N-<2-(dimethylamino)ethyl>phenanthridine-4-carboxamide (7) have been prepared and shown to have moderate in vivo antitumor activity against both the P388 leukemia and Lewis lung carcinoma.This demonstrates that t

Full text of DOI:10.1021/jm00399a015

Products guided by the article

Product name:N-<2-(methoxycarbonyl)-6-phenylphenyl>benzamide

Cas No:112422-02-3

R&D Labs maybe for 112422-02-3

Nanjing Vincero International Trading Co.,Ltd

Contact:8618936897229

Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.

Contact:+86-576-87501888 / 87501988

Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Linyi Shengxin Pharmaceutical R&D Co., Ltd

Contact:+86-18653953873

Address:West First of Yufeng Road, Yishui County
Sinonine Industry Co.,Ltd

Contact:86+21-56421993

Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Wuhan Hanye Chemical New Material Co.,Ltd

Contact:+86-27-85308141

Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China

Relevant to this article

NEW (4+2)-CYCLOADDITIONS OF IN SITU GENERATED INDOLYL ENOL ETHERS AS HETEROCYCLIC DONOR-ACTIVATED 1,3-DIENES TO CARBAZOLE DERIVATIVES

Doi:10.1016/S0040-4039(00)96290-7
(1987)
Synthesis and luminescence of cyclometalated compounds with nitrile and isocyanide ligandst

Doi:10.1021/om800845c
(2009)
Highly enantioselective transfer hydrogenation of racemic α-substituted β-keto sulfonamides: Via dynamic kinetic resolution

Doi:10.1039/c8cc01643g
(2018)
Synthesis of 2-alkoxyaryl-2-aryl enamines via tandem copper-catalyzed cycloaddition and rhodium-catalyzed alkoxyarylation from alkynes, N -sulfonyl azides, and aryl ethers

Doi:10.1021/acs.joc.5b00891
(2015)
Polyalkoxybenzenes from plant sources 2. Synthesis of isoxazoline analogs of combretastatin from natural allyl(methylenedioxy)methoxybenzenes

Doi:10.1007/s11172-007-0391-7
(2007)
Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors

Doi:10.1016/j.bmcl.2008.11.112
(2009)

Article Doi