Stereoselective routes to chiral 2-hydroxy-4-oxo acids and substituted 2-hydroxybutyrolactones using lactate dehydrogenases

Article abstract of DOI:10.1016/S0040-4039(00)74747-2

The enantioselective reduction 2,4-dioxo acids catalysed by lactate dehydrogenases provided access to 2-hydroxy-4-oxo acids of both S and R configuration. Subsequent diastereoselective chemical reduction affords 4-substituted 2-hydroxybutyrolactones.