Bile Acids with a Cyclopropyl-Containing Side Chain. 3. Separation, Identification, and Properties of All Four Stereoisomers of 3α,7β-Dihydroxy-22,23-methylene-5β-cholan-24-oic Acid

DOI: 10.1021/jm00399a007

Source and publish data:

Journal of Medicinal Chemistry p. 730 - 736 (1988)

Update date:2022-08-03

Topics: Bile Acids

Authors:

Pellicciari, Roberto

Natalini, Benedetto

Cecchetti, Sergio

Porter, Barry

Roda, Aldo

et al. et al.

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Article abstract of DOI:10.1021/jm00399a007

3α,7β-Dihydroxy-22,23-methylene-5β-cholan-24-oic acid (CUDCA) (2a), a side-chain cyclopropylog of ursodeoxycholic acid (UDCA) (1), was shown to be a mixture of four stereoisomers (CUDCA A-D).The 22S,23S (3), 22R,23R (4), 22S,23R (5), and 22R,23S (6) diast

Full text of DOI:10.1021/jm00399a007

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